disposition index, insulin secretion adjusted for ambient insulin sensitivity

disposition index - stumvoll 2005 - pdf

Bergmann 2007 DIABETES : Orchestration of Glucose Homeostasis

Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage //2008 // Muniyappa et al. 294 (1): E15. (2008) /// ***** VERY USEFUL OVERVIEW


recent thought provoking article
FAERCH 2010
DISPOSITION INDEX * insulin sensitivity - peripheral vs hepatic
Abstract
The assessment of pancreatic β cell function in humans is challenging because of a complex interplay between insulin secretion, insulin sensitivity and hepatic insulin extraction. Simplified, the relationship between insulin secretion and insulin sensitivity can be described by an approximate hyperbola with the product of the two variables being constant for individuals with the same degree of glucose tolerance (the disposition index). Strengths and limitations of the disposition index have been widely debated in the literature. In this review we will focus on another and until recently unrecognized dimension of the disposition index, namely the issue of adjusting insulin secretion for hepatic versus peripheral insulin sensitivity. An underlying assumption of this issue is that the liver as compared to muscle plays a different role in the regulation of in vivo insulin secretion